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  • Primerjava dveh trotirnih antimikrobnih shem zdravljenja okužbe z bakterijo Helicobacter pylori = The comparisson of two antimicrobial triple therapies of Helicobacter pylori infection
    Tepeš, Bojan
    Background. Helicobacter pylori is accepted as the main etiological factor forduodenal and gastric ulcer disease, MALT lymphoma, gastritis and also as class I carcinogen. The majority of European ... countries and also Slovenia have accepted national guidliness for the therapy of Helicobacter pylori infection.Triple antimicrobial therapies, based on proton pump inhibitors and two antibiotics, are accepted as therapy of choice. The results of those therapies depend on local Helicobacter pylori resistance rate to antibiotics and patients compliance. The aim of study presented was to compare two different triple antimicrobial therapies in every day clinical practice. Methods. Patients who fulfilled the indication for antimicrobial treatment of Helicobacter pylori infection in 1997 and 1998 were randomised in two groups. Patients in group A were treated with OMC (omeprazole 20 mg bid, metronidazole400 mg bid, clarithromycin 250 mg bid) for 7 days. Patients in group B were treated with OAC (omeprazole 20 mg bid, amoxycillin 1000 mg bid clarithromycin 500 mg bid) for 7 days. Before the enrollment in the study and at least two months after the end of the antimicrobial therapy upper gastrointestinal endoscopy was performed. Two biopsies were taken for rapid urea biopy test and two biopsies were taken for histology. Only Helicobacter pylori positive patients were included in the study and only if all four biopsies were Helicobacter pylori negative at the end of the study, patients were assessed as cured of infection. Results. One hundred and sixty-seven patients were enrolled in group A, and one hundred and twelve patients were cured of infection, the eradication rate is 82.6% (95% confidence interval: 79. 7%-85.5%). In group B eighty-nine patients were enrolled and seventy-threepatients were cured of infection, the eradication rate is 82% (95% confidence interval: 78%-86%). (Abstract truncated at 2000 characters)
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 69, št. 7/8, jul.-avg. 2000, str. 505-508)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - slovenski
    COBISS.SI-ID - 11832025

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