Salmonelne okužbe in imunost = Salmonella infections and immunity
Reberšek Gorišek, Jelka ; Novak, Zmago
Salmonellosis is caused by bacteria of the genus Salmonella. So far 2213 Salmonella serotypes have been described. Every Salmonella is a potential causative agent of disease in humans. The occurrence ...of disease is significantly influenced by the dose and virulence of the agent as well as theimmune capacity of the host. In our retrospective study including 186 patients we wished to investigate whether the predictive value of the course of disease can be assessed by means of risk factors and Salmonella serotypes. We analysed patient age, data regarding stomach acidity and the condition following gastric surgery, insertion of prosthetic material, taking of antibiotic and immunosuppressive therapy as well as recurrent infection. We inferred the virulence of the agent indirectly from the presentation of individual Salmonella serotypes and the inflammatory response triggered in theorganism. The study showed that of the risk factors, a predictive value canbe atributed to patient age and to the finding that none of the patients with immunosuppressive therapy and inserted artificial material had any complications during antibiotic treatment. Of all serotypes isolated in our study, Salmonella bredeney caused the strongest inflammatory response of the organism with the highest inflammatory indicators, followed by Salmonella enteritidis and Salmonella typhimurium. In these three Salmonella serotypes complications were also seen most frequently.
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