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  • Splenektomija in imunski odziv = Splenectomy and the immune response
    Kotnik, Ana, 19??
    Backgrounds: Severe trauma of the spleen can be followed by excessive internalbleeding. The life of the injured person can be saved oxtly with splenectomy. Removal of the spleen reduces resistance of ... the patient to infections, most frequently those caused by pneumococci. The most effective way of protecting these patients is vaccination with a 23-valent pneumococcal vaccine. The aim of our research was to establish at what time after splenectomy vaccination is most effective. Different possibilities were studied: vaccination just before splenectomy, vaccination one day after and seven days after splenectomy. Our hypothesis was that vaccination just before splenectomy has the best protective effect from infection. Methods. The prospective study was carried out on thirty mice divided into six groups. Their spleens were surgically removed and they were vaccinated at different times $efore or after the operation. The first group was vaccinated, without splenectomy. The second group was vaccinated just before splenectomy, the third group 1 day after and the fourth group 7 days after surgery. The fifth group had their spleens removed without vaccination,The sixth group consisted of healthy, unvaccinated mice. During the study; the mice had their blood drawn four times. With an enzyme-linked immunosorbent assay, the changing of the amount of specific IgM and IgG antibodies directed against pneumococcal antigens was measured. The amount of precipitating antibodies in the blood serum of mice was measured with a microprecipitation capillary test. The studywas concluded with a supervised infection of mice with live pneumococci. (Abstract truncated at 2000 characters)
    Vir: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 40, št. 1, mar. 2001, str. 45-63)
    Vrsta gradiva - članek, sestavni del
    Leto - 2001
    Jezik - slovenski
    COBISS.SI-ID - 13904089

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    Digitalna knjižnica Slovenije - dLib.si

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