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  • Nuclear morphometry in African breast cancer
    Ikpatt, Offiong Francis ; Kuopio, Teijo ; Collan, Yrjö
    Three hundred cases of invasive breast cancer diagnosed between 1983 and 1999 in Calabar, Nigeria were analysed to determine the nuclear morphometric variables, and evaluate the prognostic potential ... of nuclear morphometry in Nigerian breast cancers. The necessary follow-up was available for 129 patients. The nuclear area was the most valuable variable. In the Nigerian material, the mean nuclear area (MNA) (SD) was 89.2 (34.0) micro m2. MNA was significantly higher in tumours of the postmenopausal than premenopausal (p = 0.0405), in LN+ than LN- (p = 0.0202) patients, and in tumours over 3 cm than smaller ones (p < 0.0001). There were also significant differences between different clinical stages, histological grades, and histological types of tumours. Significant correlations were observed between MNA and histological grade (r = 0.64), standard mitotic index (r = 0.45) and tumour size (r = 0.20). MNA as a continuous variable was a statistically significant prognosticator in the whole material (p = 0.0281), and among the postmenopausal patients (p = 0.0238). Univariate cox's regression demonstratedone significant grading cutpoint at MNA = 111 micro m2, which divided the material into two groups of different survival. The development ofa morphometric grading system optimal for the Nigerian material could use the latter cut-point between nuclear scores 2 and 3 in the grading system. Theearlier proven cut-point of 47 pm2 could be used between nuclear scores 1 and 2.
    Vir: Image analysis & stereology : official journal of the International Society for Stereology. - ISSN 1580-3139 (Vol. 21, no. 2, jun. 2002, str. 145-150)
    Vrsta gradiva - članek, sestavni del
    Leto - 2002
    Jezik - angleški
    COBISS.SI-ID - 15131609

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