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  • Laminin-5. A potential tool in diagnosis of head and neck squamous cell carcinoma = Pomen laminina-5 v diagnostiki ploščatoceličnega karcinoma glave in vratu
    Kosmehl, Hartwing ...
    The heterotrimeric extracellular matrix protein laminin-5 (In-5) is a regular constituent of the basement membrane in oral and pharyngeal mucosa consisting of the a3, b3 and y2 chain. On the one ... hand, it is an integral part of the epithelial adhesion complex which connects the hemidesmosomes of the basal cells with the basement membrane. In this position, In-5 strictly acts againstmigration and invasion and may fundamentally contribute to the distinction between intraepithelial neoplasia vs. invasive carcinoma. On the other hand, single chains of In-5, in particular the y2 chain, are able to promote migration. The immunohistochemical In-5 demonstration outside the basement membrane in the keratinocyte cytoplasm or in the stroma of the invasive front, as well as In-5 synthesis, indicate epithelial cells potentially able to migrate and to invade. The extent of the In-5 demonstration outside the basement membrane, as well the loss of In-5 from thebasement membrane, is therefore of prognostic value. A diagnostic interpretation of In-5 immunostainings has to consider the contrary functions of In-5 or In-5 fragments: within the basement membrane it acts as anchoring protein and outside the basement membrane it represents a migration/invasion factor.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 71, supl. 3, nov. 2002, str. III-45-III-47)
    Vrsta gradiva - članek, sestavni del
    Leto - 2002
    Jezik - angleški
    COBISS.SI-ID - 15696345

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