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Novi podatki o vplivu ACE-inhibitorjev na upočasnitev ateroskleroze = New data on the effect of ACE inhibitors on retarding atherosclerosisŠabovič, MišoInhibitors of the angiotensin converting enzyme (ACE inhibitors) are well established in the treatment of arterial hypertension, heart failure and post-infarction dysfunction of the left ventricle. ... There is growing evidence that the renin-angiotensin system also plays an important role in the pathogenesis of atherosclerosis. Angiotensin II increases oxidative stress andthe consequential production of free radicals within the arterial wall. It is becoming evident that increased oxidative stress is one of the most important processes in atherosclerosis. Free radicals induce and facilitate endothelial dysfunction, inflammation in arterial walls and oxidation of LDL cholesterol. Inhibition of angiotensin II de,creases its pro-atherogenic effects. In large clinical trials (HOPE, EUROPA), ACE inhibitors (ramipril, perindopril) were found to be effective in the prevention of myocardial infarction and stroke, even in patients using aspirin, statins and beta-blockers. In the coming years, the results of other trials exploring the slowing of atherosclerosis with ACE inhibitors will become available. Overall,it is clear that treatment with ACE inhibitors is beneficial in patients with manifest atherosclerosis or high risk for it.Vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 43, supl. 1, mar. 2004, str. 1-6)Vrsta gradiva - prispevek na konferenci ; neleposlovje za odrasleLeto - 2004Jezik - slovenskiCOBISS.SI-ID - 17914585
Avtor
Šabovič, Mišo
Teme
Atherosclerosis |
Drug Therapy |
Physiopathology |
Angiotensin-Converting Enzyme Inhibitors |
Myocardial Infarction |
Prevention And Control |
Cerebral Infarction |
Prevention And Control |
Oxidative Stress |
Free Radicals |
Renin-Angiotensin System |
Angiotenzin-pretvorba, encimski inhibitorji |
Miokardni infarkt |
Možganski infarkt |
Oksidativni stres |
Prosti radikali |
Renin-angiotenzin, sistem |
kardiovaskularne bolezni |
ateroskleroza |
zdravljenje |
zdravila

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