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  • New saccharide derivatives of indolo[2,3-b]quinoline as cytotoxic compounds and topoisomerase II inhibitors
    Godlewska, Joanna ...
    Some of alkyl- and alkylamino- derivatives of 6H-indološ2,3-bđquinolines are known to be active antiproliferative and cell cycle modulating compounds. Their cytotoxic properties are, at least in ... part, due to DNA intercalation ability and topoisomerase 11 inhibition activity. To improve physicochemical and biological properties of 6H-indološ2,3-bđquinolines the series of new, saccharide (C-2, C-9 or N-6) derivatives were designed and synthesized. The influence of different carbohydrate units (D glucose, D-lactose, L-rhamnose, Lacosamine, L-daunosamine), position of attachment and linker size on cytotoxic properties and topoisomerase 11 inhibition activity were tested. Among compounds tested there were 2-deoxy-a-D glucopyranoside (1-6), 2-deoxy-alpha-L-rhamnopyranoside (7-12) and 2-deoxy-alpha-D-lactopyranoside (13-18) derivatives in the group of saccharide moiety containing compounds anda-L-daunosaminide (19-24) and a-L-acosaminide (2527) in the aminosaccharidederivatives series as well.
    Vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 38, no. 2, jun. 2004, str. 137-144)
    Vrsta gradiva - članek, sestavni del
    Leto - 2004
    Jezik - angleški
    COBISS.SI-ID - 18167513

    Povezava(-e):

    Digitalna knjižnica Slovenije - dLib.si

vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 38, no. 2, jun. 2004, str. 137-144)

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