Narodna in univerzitetna knjižnica, Ljubljana (NUK)
Naročanje gradiva za izposojo na dom
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi
  • Eksperimentalna kardiologija: električni, mehanični in nevrohumoralni učinki hitrega spodbujanja preddvorov pri raziskovalnem modelu na psih
    Zupan, Igor, 1961-
    Introduction. The objectives of the present study were to evaluate the effectsof high-rate pacing on sinus node function and intra-atrial conduction;to compare the relationship between mechanical ... remodeling and atrial electrophysiology and to compare the influence of mechanical remodelingon the increase of plasma renin activity (PRA) and atrial natriuretic peptide secretion (ANP).Methods. Eight dogs were subjected to rapid atrial pacing (AP) at a rate of 400 beats/min for 16 days. After a complete recovery of left ventricular function, they underwent rapid ventricular pacing (VP) of 240 beats/min of equal duration. Sinus node recovery time (SNRT) was obtained in right atrial site at three pacing rates. Atrial effective refractory period (AERP) was measured at cycle lengths 300 and 400 ms, respecively. Left atrial systolic maximal dimension (LAmax) was assessed by echocardiography. Blood samples were taken from the right atrium and from the peripheral vein. Measurements were performed at baseline, immediately after AP or VP, and four weeks after termination of AP or VP.Results. SNRT immediately after AP and VP was significantly prolonged at all three pacing rates (p<0.03). P-wave duration increased significantly aftereither type of pacing compared with baseline values. AERP at a basic cycle length of 400 ms decreased significantly after either type of pacing compared with baseline values; the difference between tachycardias was significant too (p<0.02). Significant increases (p<0.05) in left atrial dimensions (LA-A) indicated atrial dilatation after either type of pacing, thedifferences between two groups being insignificant. Atrial reversal pulmonary venous flow (AR velocity) decreased in AP and VP. The difference washighly significant as compared to basal values and also with respect to both tachycardias (p<0.01). In both groups, atrial remodeling occurred in a relatively short period of time. (Abstract truncated at 2000 characters).
    Vir: Slovenska kardiologija : znanstveno strokovna revija za področje srčno-žilne medicine. - ISSN 1581-8543 (Letn. 1, št. 2, okt. 2004, str. 4-14)
    Vrsta gradiva - članek, sestavni del
    Leto - 2004
    Jezik - slovenski
    COBISS.SI-ID - 18749913

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