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  • Ocena tipa in aktivnosti vnetja pri bolnikih z obstruktivno pljučno boleznijo = Type and activity of inflammation in obstructive lung diseases
    Avčin, Simona ; Jezernik, Matej
    Airway inflammation is fundamental to the persistence of asthma and chronic obstructive pulmonary disease. The hypothesis that induced sputum cell counts and mediators could help discriminate between ... between asthma and chronic obstructive pulmonary disease was tested. Cell counts and the concentration ofECP and PMN elastase were measured in induced sputum and serum of 21 healthysubjects,17 patients with asthma and 6 with stable chronic obstructive pulmonary disease. Induced sputum eosinophils were significantly higher in case of asthma (8.2 10.8%) than in healthy subjects (0.3 0.6%) (p < 0.05),but chronic obstructive pulmonary disease (2.4 1.9). Neutrophil counts were significantly higher in patients with chronic obstructive pulmonary disease (89.5%, S. D. 2.0%) than in those with asthma (65.8%, S. D. 23.7%) (p < 0.05). Induced sputum ECP were higher in asthma (148 104mig/1) and chronicobstructive pulmonary disease (113 122mig/1) than in healthy subjects (48 37mig/1) (p < 0.05). Eosinophil counts and ECP concentration in induced sputum could be used to discriminate between patients with asthma and healthy subjects. Neutrophil counts in induced sputum could be used to discriminate between patients with chronic obstructive pulmonary disease and asthma. However, measurement of ECP and PMN elastase concentration in induced sputum and serum would not discriminate between patients with chronic obstructive pulmonary disease and asthma.
    Vir: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 44, št. 4, dec. 2005, str. 425-433)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - slovenski
    COBISS.SI-ID - 20679641

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    Digitalna knjižnica Slovenije - dLib.si

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