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  • Genetika sindroma policističnih jajčnikov - vloga mikrosatelitskega polimorfizma (TAAAA)n v genu SHBG
    Ferk, Polonca ; Čelhar, Teja ; Geršak, Ksenija
    Polycystic ovary syndrome (PCOS) is a complex disease, with extremely heterogeneous clinical presentation and a possible genetic background. Hyperandrogenism is one of the key features in PCOS. Among ... numerous PCOS candidate genetic polymorphisms, the microsatellite polymorphism (TAAAA)n in the promoter of the SHBG gene has also been proposed. The SHBG gene encodes for specific sex hormone binding globulin (SHBG), which influences the proportion of bioavailable androgens, and the polymorphism regulates the SHBG gene's expression. In the present study on 118 PCOS women and 108 healthy volunteers, possible associations of the (TAAAA)n SHBG polymorphism with serumSHBG levels and with the development of PCOS were investigated. Both groups of patients differed significantly in their biochemical and clinical profiles. The polymorphism was ascertained to be a strong predictor for serum SHBG levels; longer alleles were associated with lower serum SHBG levels and thus with higher risks for hyperandrogenism in PCOS. Rather than the (TAAAA)n SHBG polymorphism as the only genetic susceptibility factor, a specific combination of several genetic polymorphisms modified by environmental factorsmight be involved in the development of the whole spectrum of PCOS clinical picture.
    Vir: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 58, št. 1, mar. 2007, str. 21-28)
    Vrsta gradiva - članek, sestavni del
    Leto - 2007
    Jezik - slovenski
    COBISS.SI-ID - 22908121

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    Digitalna knjižnica Slovenije - dLib.si

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