-
3D-conformal radiotherapy for inoperable non-small-cell lung cancer : a single centre experienceFromm, Sabine ...Background. The purpose of this investigation was to evaluate feasibility, safety and efficacy of 3D conformal radiotherapy (3D-RT) for inoperable non-small-cell lung cancer (NSCLC). Time to ... progression (TTP), including localrecurrence and/or distant metastasis, local control rate (LCR), time to death (TTD) and side effects were evaluated. Patients and methods. From 1997 to 2002, a total of 84 patients with inoperable NSCLC were treated with 3D-RT according to a prospective protocol at our institution. Depending on performance status, lung function and dose-volume constraints, radiation dosesof either 66-70 Gy or 50-60 Gy +/- platin-based chemotherap were applied.Results. The treatment was well tolerated and the rate of side effectswas low. Only one grade 4 pneumonitis was observed, the rate of grade 3pneumonitis was 6% and 13% for grade 2. Two patients developed a grade 4 oesophagitis and no grade 3 oesophageal toxicity was observed. The analysis ofdose-volume histograms (DVH) found a mean V20 (lung volume that receives 20 Gy) for the ipsilateral lung (IL) of 42%, a mean V20 for the contralateral lung (CL) of 14% and a mean lung dose IL of 25 Gy. The mean V20 IL in patientsdeveloping a pneumonitis grade 2-4 was 53.3%. The mean follow-up was 24 month. There was no difference in TTP (median 15 months) in the different treatment groups. Patients receiving higher radiation doses (66-70 Gy) had a benefit in an overall survival (OS) when the additional chemotherapy was applied (28 month vs. 16 month). Local control rates of mean 22% after 2 yearswere low. Conclusions. The application of radiation doses up to 70 Gy is feasible and safe, also in combination with chemotherapy. Still, the local control and OS is poor. Thus, further trials to investigate the possibility ofdose escalation in the lung without increasing lung toxicity significantly, also in more advanced tumour stages, are mandatory.Vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 41, no. 3, sep. 2007, str. 133-143)Vrsta gradiva - članek, sestavni delLeto - 2007Jezik - angleškiCOBISS.SI-ID - 23501273
Avtor
Fromm, Sabine |
Rottenfusser, Andrea |
Berger, Daniel |
Pirker, Robert |
Pötter, Richard |
Pokrajac, Boris
Teme
Lung Neoplasms |
Radiotherapy |
Carcinoma, Non-Small-Cell Lung |
Radiotherapy Planning, Computer-Assisted |
Dose-Response Relationship, Radiation |
Survival Analysis |
Doza-odgovor, odnos, sevanje |
Karcinom nemalocelični, pljučni |
Pljučne novotvorbe |
Preživetje, analiza |
Radioterapija, planiranje z računalnikom |
pljučni rak |
pljuča |
zdravljenje |
radiologija |
radioterapija
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Fromm, Sabine | |
Rottenfusser, Andrea | |
Berger, Daniel | |
Pirker, Robert | |
Pötter, Richard | |
Pokrajac, Boris |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi