Narodna in univerzitetna knjižnica, Ljubljana (NUK)
Naročanje gradiva za izposojo na dom
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi
  • Prisotnost deleža mutiranega alela JAK2 V617F pri kroničnih mieloproliferativnih boleznih = JAK2 V617F allele burden in chronic myeloproliferative diseases
    Škerget, Matevž ...
    Background Chronic myeloproliferative disorders (CMPD) are a group of conditions affecting the stem cell causing over-production of one or more of the blood cells. The presence of Ph chromosome ... distinguishes chronic myeloid leukemia (CML) from other diseases of the group. JAK2 V617F mutation is present in 76-97% of patients with polycythaemia vera (PRV), 29-75% of patients with essential thrombocythaemia (ET) and 50% of patients with chronicidiopathic myelofibrosis (CIMF). The JAK2 V617F allele burden correlates with the clinical picture of the diseases. Methods We involved 110 patients with ET, PRV and CIMF in whom we already had extracted DNA samples from granulocytes. We established the JAK2 V617F allele burden in the DNA of granulocytes by using real-time polymerase chain reaction (RQ-PCR). Results The mean allele burden of JAK2 V617F is 25% in patients with ET, 47% in patients with PRV and 85% in patients with CIMF. There is a statistically significant correlation between the allele burden and the number of leukocytesin peripheral blood. Conclusion The mean allele burden of JAK2 V617Fis different in ET, PRV and CIMF. It is plausible that the three seperatediseases are only different clinical pictures of the same CMPD depending on the allele burden. The allele burden strongly correlates with theperipheral blood count.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 77, supl. 1, apr. 2008, str. I-57-I-61)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2008
    Jezik - slovenski
    COBISS.SI-ID - 24128473

    Povezava(-e):

    Digitalna knjižnica Slovenije - dLib.si

Vnos na polico