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  • Can supplementation with vitamin E or C and omega-3 or -6 fatty acids improve the outcome of schizophrenia?
    Bošković, Marija ; Vovk, Tomaž, 1972-
    Background: Schizophrenia is a major mental disorder associated withhigh morbidity and economic cost. It is important to develop alternative or supplementary treatment strategies that could augment ... antipsychotic actionsand reduce side effects. Increasing evidence indicate that oxidative damage is present in patients with schizophrenia. Oxidative mediated damage issuggested by an increase in lipid peroxidation products in cerebrospinal fluid and plasma, and a reduced concentration of membrane polyunsaturated fatty acids in neurons. Lipid peroxidation can be prevented by antioxidant supplementation and on the other hand the process of phospholipids regeneration can be increased by supplementation with essentially fatty acids.Objective: To review available data on the clinical effects of vitamin Eor C and omega-3 or -6 fatty acids for supplementary treatment of patients with schizophrenia. Main results: Trials on a limited number of subjects with an uncertain quality of randomisation indicate that vitamin E protects againstdeterioration of tardive dyskinesia but there is no evidence that vitamin E supplementation improves symptoms of tardive dyskinesia. As concernsvitamin C, there is not enough data for evaluation. Until now, the results show that oral supplementation with vitamin C restore ascorbic acid levels, reduce oxidative stress, and improve Brief Psychiatric Rating Scale score. The results of supplementation therapy with polyunsaturated fatty acidsremain inconclusive. Omega-3 fatty acids have the greatest potential of all fatty acids to reduce movement disorder outcomes as expressed by the Abnormal Involuntary Syndrome Scale score. Combined therapy with antioxidants and polyunsaturated fatty acids is the most promising approach to prevent oxidative damage and enable regeneration of phospholipids in neurons, but its potential has to be confirmed in future clinical studies. Conclusion: The use of antioxidants and omega-3 polyunsaturated fatty acids in adjuvant treatment of schizophrenia still remains hypothetical and there is a need for large, well designed and reported studies. Potentially it could be an effective, low cost, supplementary treatment with few side effects. Therefore, such therapy would be a significant advance in schizophrenia.
    Vir: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 59, št. 4, okt. 2008, str. 167-173)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - angleški
    COBISS.SI-ID - 2417009

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    Digitalna knjižnica Slovenije - dLib.si

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