Narodna in univerzitetna knjižnica, Ljubljana (NUK)
Naročanje gradiva za izposojo na dom
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi
  • Test aktivacije bazofilcev (BAT) v in vitro diagnostiki pri preobčutljivosti za strup kožekrilcev = Basophil activation test (BAT) in "in vitro" diagnosis of hymenoptera venom hypersensitivity
    Premoša, Andreja, 1979- ...
    Background The basophil activation test relies on flow cytometric quantitationof the expression of the markers on the surface of basophils, after stimulation with the amount of allergen that ... cross-link IgE antibodies bound on their surface. In allergy diagnosis, the technique has been applied in the investigation of IgE-mediated allergy caused by classical inhalant allergens, Hevea latex, food, drugs and hymenoptera venoms. The technique alsoproves valuable in the diagnosis of non-IgE-mediated reactions such as drug hypersensitivity and the detection of autoantibodies in certain forms of chronic urticaria. To strengthen the probability that the working diagnosis for hymenoptera venom hypersensitivity is correct, confirmatory testing for skin test and IgE antibody is often performed. But sometimes clinical history and the results of confirmatory tests are contradictory. In such cases additional tests are necessary, among which flow cytometric quantification of in vitro basophil activation is becoming a valuable tool during the last few years. Material and methods In Laboratory for Clinical Immunology and Molecular Genetic, Golnik, we performed BAT for 127 patients with history of anaphylactic reactions after Hymenoptera sting. Conclusions According to our findings BAT is a highly sensitive and specific technique and as an in vitro provocation assay enables sensibilisation detection, prediction of side effects from specific immunotherapy and differentiates between clinically relevant and irrelevant epitops. This technique also gave us a new informationon mechanisms and effects of venom immunotherapy.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 77, št. 3, mar. 2008, str. 183-187)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - slovenski
    COBISS.SI-ID - 24198873

    Povezava(-e):

    Digitalna knjižnica Slovenije - dLib.si

Vnos na polico