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  • Antikoagulacijsko zdravljenje pri bolnikih z zmanjšanim ledvičnim delovanjem = Anticoagulant treatment in patients with renal insufficiency
    Tratar, Gregor ...
    Background In the recent years, the number of patients treated with anticoagulant therapy is increasing. Among them, there is also an increased number of patients with renal insufficiency. Due to ... changes in coagulation andfibrinolityc system activity these patients are at increased risk of bleeding and thrombotic complications when treated with anticoagulants. Unfractionated heparin, low-molecular-weight-heparins and vitamin K antagonistare used for anticoagulant therapy in patients with renal insufficiency. Dosing of unfractionated heparin and vitamin K antagonists in these patients does not differ from dosing in patients without renal disease. However, special caution should be taken when using low molecular weight heparins for therapy or prophylaxis in patients with renal insufficiency. Low-molecular-weight-heparins are cleared principally by renal route and theirbiological half-life is prolonged in patients with renal insufficiency. If low-molecular-weight-heparin is chosen for anticoagulant therapy, monitoring should be performed with anti-factor Xa activity measurements. Clinicians are often required to decide on how to manage patients receiving long-term anticoagulant therapy during and after invasive nephrological procedures. Conclusions This article summarizes recommendations on use of anticoagulant drugs in patients with renal insufficiency. It also suggests management of these patients before and after invasive nephrological procedures including renal transplantation.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 77, št. 4, apr. 2008, str. 299-305)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - slovenski
    COBISS.SI-ID - 24223705

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    Digitalna knjižnica Slovenije - dLib.si

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