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  • Intracoronary and systemic levels of inflammation markers in patients with coronary artery disease = Vpliv lokalnega vnetnega dogajanja na stabilnost aterosklerotičnih plakov
    Kirbiš, Simona, 1976- ...
    Aim. Intracoronary and systemic plasma levels of circulating markers of (vascular) inflammation were compared in order to determine the role of local and systemic origin of inflammation in patients ... with coronary artery disease. Patients and methods. Patients with acute coronary syndrome (ACS) (N=11) and stable angina pectoris (N=10), and controls (N=9) were included in the study. Intracoronary blood samples were taken at the culprit lesion and the unaffected left or right coronary artery from patients with ACS, and from the left and right coronary artery in other two groups. Systemic blood samples were taken from the femoral vein and femoral artery. High sensitivity C reactive protein (hsCRP), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), soluble receptor for interleukin 2 (tR IL-2) and myeloperoxidase (MPO) were measured in all obtained blood samples. Results. Nodifference was found between intracoronary and systemic levels of all inflammatory markers in ACS patients and in patients with stable angina. Importantly, no difference was detected when the levels of inflammatory markers at the culprit lesion were compared to those from an unaffected coronary artery in patients with ACS. However, patients with ACS had significantly elevated (intracoronary and systemic) levels of hsCRP and IL-10 compared to those with stable angina and controls. No difference in any markerexisted between patients with stable angina and controls. Conclusion. Our results strongly suggest that systemic rather than local vascular inflammation is crucial for the increased inflammation state present in patients with CAD, particularly patients with ACS.
    Vir: Slovenska kardiologija : znanstveno strokovna revija za področje srčno-žilne medicine. - ISSN 1581-8543 (Vol. 5, iss. 1, 2008, str. 16-21)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - angleški
    COBISS.SI-ID - 24470745

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