-
Endotelijski hiperpolarizirajoči dejavnik in mikrocirkulacija kože = Endothelium-derived hyperpolarizing factor and skin microcirculationLenasi, Helena, 1971-The skin microcirculation is controlled by systemic and local factors; the latter are mainly released from the endothelium. One of important endothelial vasodilators is endothelium-derived ... hyperpolarizing factor (EDHF) whose function can be assessed by blocking ocher vasodilators, such as nitric oxide (NO) and prostacyclin (PGIZ). The role and nature of EDHF in humans remains tobe elucidated. The aim of our study was therefore to investigate and characterize the NO- and PGhindependent mechanism, potentially attributable toEDHF, in human skin microcirculation. 14 healthy male volunteers (aged 20 to37 years, mean age 25.9 +- 1.7) were included in the study. Cutaneous blood flow was measured using the laser Doppler (LD) method on the volar aspect of the forearm and expressed in perfusion units (PU). Endothelial nitric oxide synthase (eNOS) and cyclooxygenase (COX) were inhibited by subcutaneously injecting N°'-monomethyl L-arginine (L-NMMA) and diclofenac, respectively. Thepotential involvement of cytochrome P450 (CYP) in the generation of EDHF was evaluated by injecting the selective CYP 2C9 inhibitor sulfaphenazole. Thebaseline LD flow and microvascular reactivity were assessed by performing iontophoresis of acetylcholine (ACh, endothelium-dependent vasodilator) and bymeasuring postocclusive reactive hyperemia (PRH). eNOS and COX inhibition did not affect the baseline LDF (12.5 +- 2.3 PU in the treated site and 10.9 +- 1.8 PU in the control site, t-test), but it significantly attenuated ACh-induced vasodilatation in the eNOS and COX-treated site (35.6+-5.7PU in the treated site vs. 66.6 +- 8.3 PU in the control site, t-test, p < 0.05). (Abstract truncated at 2000 characters)Vir: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 47, št. 1, mar. 2008, str. 13-29)Vrsta gradiva - članek, sestavni delLeto - 2008Jezik - slovenskiCOBISS.SI-ID - 24580825
Avtor
Lenasi, Helena, 1971-
Teme
Skin |
Blood Supply |
Microcirculation |
Laser-Doppler Flowmetry |
Endothelium, Vascular |
Vasodilation |
Adult |
Cyclooxygenase Inhibitors |
Diclofenac |
Nitric-Oxide Synthase |
Antagonists And Inhibitors |
Ionophores |
Prostaglandins |
Cytochrome P-450 |
Endotelij žilni |
Koža |
Mikrocirkulacija |
Vazodilatacija |
Laser-dopplersko merjenje hitrosti pretoka |
Citokrom P-450 |
Prostaglandini |
Diklofenak |
Dušikov-oksid, sintaza |
Odrasli |
Ciklooksigenazni inhibitorji |
Ionofori |
koža |
prekrvavitev |
mikrocirkulacija |
žilni endotelij
vir: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 47, št. 1, mar. 2008, str. 13-29)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|---|
Lenasi, Helena, 1971- | 18322 |
Izberite prevzemno mesto:
Prevzem gradiva po pošti
Obvestilo
Gesla v Splošnem geslovniku COBISS
Izbira mesta prevzema
Mesto prevzema | Status gradiva | Rezervacija |
---|
Prosimo, počakajte trenutek.
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi