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  • Holin-esteraze : struktura, delovanje ter inhibicija z naravnimi in sintetičnimi strupi = Cholinesterases : structure, mechanism and inhibition by natural and synthetic poisons
    Stojan, Rok ; Stojan, Žiga ; Stojan, Jure, 1956-
    Cholinesterases are involved in terminating nerve impulses in the central nervous system and at the periphery. The high enzyme concentration at the cholinergic synapses is achieved by oligomerization ... on an anchoring, collagen-like peptide. The 3D structure of a monomer shows a buried active site, which is responsible for the effectiveness and specificity of the enzyme, but also for various pseudocooperative phenomena. Due to its importantrole, acetylcholinesterase is a target for various inhibitors, natural as well as artificial ones. Reversible inhibitors prevent substrate accommodation by stericaily blocking the active site and the irreversible onesact as acylating agents that modify the active site serine, the major participant in covalent catalysis. When irreversibly inhibited by potent nervegases, cholinesterases can be reactivated, unless partial dealkylation ofthe bound inhibitor has occurred. This particular phenomenon, called aging of cholinesterases, along with generalized cytotoxic effect appear to be the cause of organophosphate-induced delayed neurotoxicity in nerve gas poisoned casualties.
    Vir: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 47, št. 3, sep. 2008, str. 293-307)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - slovenski
    COBISS.SI-ID - 25427417

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    Digitalna knjižnica Slovenije - dLib.si

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