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  • Genetic epidemiology and heritability of vitiligo in the Qassim region of Saudi Arabia
    Alzolibani, Abdullateef
    Aim: Assessment of consanguinity and inheritance patterns in relation to clinical subtypes of vitiligo among Saudi cases in the Qassim region based on a vitiligo case series during 2008 taken from ... the Qassim University-affiliatedreferral center. Methods: This study included 111 randomly selected Saudi probands affected by vitiligo and their families. Theyincluded 61 males and 50 females. Their mean age of onset was 19.13 11.97 years. Data were collected using a questionnaire administered by professional dermatologists emphasizing the clinical features as well as consanguinity and segregation pattern. Genetic analyses for inbreeding coefficient, mode of inheritance, and heritability were statistically analyzed. Results: Out of 111 probands, the frequencies of focal, vulgaris, universal, and acrofacial subtypes were 32.4%, 31.5%, 9.9%, and 26.1%, respectively. Parental consanguinity was positive in 32.4% of cases and first-cousin consanguinity in 22.5% with an inbreeding coefficient of 0.015. The family history was positive in 56.8% of cases. The mean age of onset was 19.13 11.97 years with a median of 17 years. The median age of onset was lower for consanguineous cases and cases with a positive family history. Inheritance patterns coincided more with the multifactorial model, especially for the vulgaris subtype followed by the acrofacial subtype, and coincided least with the focal subtype. Heritability or the genetic contribution to the disease showed a high weighted mean of 0.54.
    Vir: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Vol. 18, no. 3, sep. 2009, str. 119-125)
    Vrsta gradiva - članek, sestavni del
    Leto - 2009
    Jezik - angleški
    COBISS.SI-ID - 26520537

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    Digitalna knjižnica Slovenije - dLib.si

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