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  • Anti-fungal medication and sarcoidosis = Antimikotiki in sarkoidoza
    Terčelj-Zorman, Marjeta ; Salobir, Barbara, 1966- ; Rylander, Ragnar
    Background: Previous studies on sarcoidosis have shown that the addition of ananti-fungal medication to the traditional treatment with corticosteroids improves treatment efficiency. It cannot be ... excluded that the effect is due toa stimulatory effect of the anti-fungal medication on the action of corticosteroids. To assess this possibility a study was undertaken where patients with sarcoidosis stage 2 were given an antifungal medication only. Material and methods: Study subjects (n=10) were recruited from newly diagnosed cases of sarcoidosis and observed for 3 months to reduce the risk ofincluding patients with spontaneous regression of the disease. They were given an anti-fungal medication for 2-11 months and x-rays were taken before and every second month after starting the treatment. Diffusion capacity, serumangiotensin converting enzyme, and chitotriosidase were determined as markers of sarcoidosis activity. Results: There were improvements in the x-rayfindings as well as the markers of sarcoidosis in 8 out of 10 patients. Two patients had an exacerbation of their disease after two months and they were given corticosteroids in addition to the anti-fungal medication. Comments: The results demonstrate that the beneficial effects of anti-fungal medication are specific and not caused by an improvement of corticosteroid efficacy. The findings provide a basis for larger clinical studies.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 79, št. 12, dec. 2010, str. 825-828)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 27829209

    Povezava(-e):

    http://szd.si/user_files/vsebina/Zdravniski_Vestnik/2010/december/825-8.pdf
    Digitalna knjižnica Slovenije - dLib.si

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