Narodna in univerzitetna knjižnica, Ljubljana (NUK)
Naročanje gradiva za izposojo na dom
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi
PDF
  • Expression of NF-kB p65 phosphorylated at serine-536 in rectal cancer with or without preoperative radiotherapy
    Lewander, Andreas ...
    Background. In the present study, we investigated NF-êB p65 phosphorylated at Serine-536 (phosphor-Ser536-p65) in rectal cancer and its relationship to preoperative radiotherapy (RT), ... clinicopathological variables and biological factors.Patients and methods. Expression of phosphor-Ser536-p65 was examined by using immunohistochemistry in 141primary rectal cancers, 149 normal mucosa specimens and 48 metastases in the lymph nodes, from rectal cancer patients who participated in a Swedish clinical trial of preoperative RT. Results. The expression of phosphor-Ser536-p65 in the cytoplasm increased from normal mucosa to primary tumour (p<0.0001, for both the group that did and the group that did not received RT). The expression did not further increase from primary tumour to metastasis in either group (p>0.05). Expression of phosphor-Ser536-p65 was positively related to, or tended to be related to, theexpression of tumour endothelium marker 1 (TEM1, p=0.02), FXYD-3 (p=0.001),phosphatase of regenerating liver (PRL, p=0.02), p73 (p=0.048) and meningioma associated protein (MAC30, p=0.05) in the group that received RT but there were no such relationships in the group that did not received RT (p>0.05). The expression of phosphor-Ser536-p65 was not related to clinicopathological factors including survival (p>0.05). Conclusions. The increased expression of phosphor-Ser536-p65 may be involved in rectal cancer development. After RT, phosphor-Ser536-p65 seems to be positively related to the biological factors, which associated with more malignant features of tumours. However, phosphor-Ser536-p65 was not directly related to the responseof RT based on recurrence and survival.
    Vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 45, no. 4, 2011, str. 279-284, III)
    Vrsta gradiva - članek, sestavni del
    Leto - 2011
    Jezik - angleški
    COBISS.SI-ID - 29635289

    Povezava(-e):

    Digitalna knjižnica Slovenije - dLib.si
    DOI

vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 45, no. 4, 2011, str. 279-284, III)

loading ...
loading ...
loading ...

Vnos na polico