Influence of transient response of platinum electrode on neural signals during stimulation of isolated swinish left vagus nerve = Vpliv prehodnega značaja platinaste elektrode na živčni signal med stimulacijo izoliranega živca vagusa svinje
Pečlin, Polona ...
The main aim of the work was to measure transient response characteristics of interface between platinum stimulating electrodes and isolated swinish left cervical vagus nerve (segment), when ...electrical stimulating pulses are appliedto preselected locations along the segment and elicited neural signals,also described as compound action potentials (CAPs), are recorded fromparticular compartments of the nerve. The stimulating system was manufactured as a silicone self-coiling spiral cuff (cuff) with embedded matrix of ninety-nine rectangular electrodes (0.5 mm in width and 2mm in length), made of 45 microm thick annealed platinum ribbon (99.99 % purity), and a geometric surface of 1 mm2. For electrical stimulation, a current quasitrapezoidal, asymmetric and biphasic pulses with frequency of 1 Hz, were used. To test an influence of stimulating pulses having different parameters and waveforms on elicited CAPs, various degree of imbalance between an electric charge (charge) injected in cathodic phase as well as charge injectedin anodic phase of a biphasic stimulating pulse, were deployed and compared. To identify the differences in elicited CAPs however, an integral ofthe CAP cathodic phase as well as integral of the CAP anodic phase of stimulating pulse, were calculated and compared. Results showed a strong component superimposed in the CAPs, considered as an ensemble artefact which greatly obscured the components of the CAPs, and various components did overlap. Results also showed that stimulating pulses, having preset certain degree of imbalance between charge injected in cathodic and charge injected inanodic phase, elicited a slight change in a positive waveform deflection of CAP manifested under a cathodic phase as well as slight change in a negative waveform deflection of CAP manifested under an anodic phase. (Abstract truncated at 2000 characters)
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