Narodna in univerzitetna knjižnica, Ljubljana (NUK)
Naročanje gradiva za izposojo na dom
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi
  • Design, synthesis and in vitro biochemical activity of novel amino acid sulfonohydrazide inhibitors of murC
    Frlan, Rok ...
    Mur ligases are essential enzymes involved in the cytoplasmic steps of peptidoglycan synthesis which remain attractive, yet unexploited targets. In order to develop new antibacterial agents, we have ... designed a series of new MurC and Mur- D inhibitors bearing amino acid sulfonohydrazide moiety. The L-Leu series of this class displayed the highest enzyme inhibition with IC50 in the concentration range between 100 and 500 ìM, with L-Thr, L-Pro and L-Aladerivatives being inactive. The most promising compound of the series also expressed weak antibacterial activity against S. aureus with MIC = 128 [micro]g/mL.
    Vir: Acta chimica slovenica. - ISSN 1318-0207 (Vol. 58, no. 2, 2011, str. 295-310)
    Vrsta gradiva - članek, sestavni del
    Leto - 2011
    Jezik - angleški
    COBISS.SI-ID - 3047281

    Povezava(-e):

    http://acta.chem-soc.si/58/58-2-295.pdf
    http://acta.chem-soc.si/58/Graph/acta-58%282%29-GA.htm
    Digitalna knjižnica Slovenije - dLib.si

vir: Acta chimica slovenica. - ISSN 1318-0207 (Vol. 58, no. 2, 2011, str. 295-310)

loading ...
loading ...
loading ...

Vnos na polico