Narodna in univerzitetna knjižnica, Ljubljana (NUK)
Naročanje gradiva za izposojo na dom
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi
  • Hormeza - primer odgovora astrocitov po izpostavljenosti etanolu = Hormesis - an example of astrocyte response after ethanol exposure
    Lipnik-Štangelj, Metoda ; Šarc, Lucija, 1968-
    Purpose: In the present work we describe hormesis and review documented hormetic responses in astroglial cells after exposure to different stressors. We present an example of the astrocyte response ... to acute and chronic ethanol exposure with hormetic characteristics. Methods: As an experimental model, newborn rat cortical astrocytes in culture were used. The cells were exposed to ethanol or the primary metabolite of ethanol (acetaldehyde) for 24 h or 7 days. After treatment, the protein content was determined, and the IL-6 levelsin the culture medium were measured using an enzymelinked immunoassay. Results: Treatment of astroglial cells with ethanol or acetaldehyde led to enhanced protein content and stimulated IL-6 production in the low concentration zone followed by diminished protein content and an inhibition ofIL-6 production at higher concentrations. Chronic exposure of astrocytes wasmore toxic than acute exposure for both compounds, and acetaldehyde was more toxic compared to ethanol. Conclusion: Ethanol and acetaldehyde representstressors for cultured astrocytes and evoke a typical hormetic response after acute and chronic exposure.
    Vir: Acta medico-biotechnica : AMB. - ISSN 1855-5640 (Vol. 5, [no.] 2, 2012, str. 65-72)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 512240440

    Povezava(-e):

    Digitalna knjižnica Univerze v Mariboru – DKUM
    Digitalna knjižnica Slovenije - dLib.si

vir: Acta medico-biotechnica : AMB. - ISSN 1855-5640 (Vol. 5, [no.] 2, 2012, str. 65-72)

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