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  • CA19-9 serum levels predict micrometastases in patients with gastric cancer
    Jagrič, Tomaž ...
    Background. We explored the prognostic value of the up-regulated carbohydrate antigen (CA19-9) in node-negative patients with gastric cancer as a surrogate marker for micrometastases. Patients and ... methods. Micrometastases were determined using reverse transcription quantitative polymerase chain reaction (RT-qPCR) for a subgroup of 30 node-negative patients. This group was used to determine the cut-off for preoperative CA19-9 serum levels as a surrogate marker for micrometastases. Then 187 node-negative T1 to T4 patients were selected to validate the predictive value of this CA19-9 threshold. Results. Patients with micrometastases had significantly higher preoperative CA19-9 serum levels compared to patients without micrometastases (p = 0.046). CA19-9 serum levels were significantly correlated with tumour site, tumour diameter, and perineural invasion. Although not reaching significance, subgroup analysis showed better five-year survival rates for patients with CA19-9 serum levels below the threshold, compared to patients with CA19-9 serum levels above the cut-off. The cumulative survival for T2 to T4 node-negative patients was significantly better with CA19-9 serum levels below the cut-off (p = 0.04). Conclusions. Preoperative CA19-9 serum levels can be used to predict higher risk for haematogenous spread and micrometastases in node-negative patients. However, CA19-9 serum levels lack the necessary sensitivity and specificity to reliably predict micrometastases.
    Vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 50, no. 2, Jun. 2016, str. 204-211, VI)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2016
    Jezik - angleški
    COBISS.SI-ID - 5741375

    Povezava(-e):

    http://ojs.szd.si/index.php/ro/article/view/2257/1872
    Digitalna knjižnica Slovenije - dLib.si
    DiRROS - Digitalni repozitorij raziskovalnih organizacij Slovenije
    DOI

vir: Radiology and oncology. - ISSN 1318-2099 (Vol. 50, no. 2, Jun. 2016, str. 204-211, VI)

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