Narodna in univerzitetna knjižnica, Ljubljana (NUK)
Naročanje gradiva za izposojo na dom
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi
  • Vpliv famotidina in kloropiramina na ishemično okvaro pri izoliranem podganjem srcu
    Burjak, Mateja
    In the present study the effects of either H1 antagonist chloropyramine or H2 antagonist famotidine were investigated in isolated Langendorff's rat hearts. Ischemia lasted 60 minutes. Perfusion with ... either 10 micro mol/l chloropyramine or 10 micro mol/l famotidine was initiated 10 minutes before ischemia and lasted till the end of the experiments. Registered were letf ventricular pressure, heart rate, Q, coronary flow and ECG. The temperature inthe left ventricle was kept at 38.5 -+- 0.5 deree C. The extent of myocardial damage was assessed by the release rate of the enzyme lactate dehydrogenase. In control experiments chloropyramine had negative chronotropiceffect and increased Q. Its addition decreased the coronary flow during reperfusion, caused bradicardia and did not influence the lactate dehydrogenase release. In control experiments famotidine had positive inotropic and positive chronotropic effects and decreased Q. In control experiments famotidine increased the coronary flow. During reperfusion famotidine induced tachycardia and fibrillation. Famotidine did not influence the lactate dehydrogenase release during reperfusion. Results of our experiments indicate that in the rat heart additionaly to H1 receptors also H2receptors might exist and that both of them could be involved in the myocardial damage induced by ischaemia and reperfusion.
    Vir: Medicinski razgledi : [medicinski pregledni, strokovni in raziskovalni članki]. - ISSN 0025-8121 (Letn. 35, [št. ] 4, dec. 1996, str. 473-489)
    Vrsta gradiva - članek, sestavni del
    Leto - 1996
    Jezik - slovenski
    COBISS.SI-ID - 7374041

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    Digitalna knjižnica Slovenije - dLib.si

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