Narodna in univerzitetna knjižnica, Ljubljana (NUK)
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  • Določanje nivoja terbinafinijevega hidroklorida v dlaki mačk in v laseh otrok, obolelih za mikrosporozo in zdravljenje s tabletami Lamisil = Determination of the terbinafine hydrochloride levels in hair of cats and children infected with Microsporum canis and treated with Lamisil tablets
    Kužner, Jernej ; Kožuh Eržen, Nevenka ; Drobnič-Košorok, Marinka
    Concentration of terbinafine hydrochloride (Lamisil) in hair of cats and children is a very important indicator for the evaluation of the drug and treatment effectiveness. A sensitive, fast, reliable ... and cost effective methodfor the routine determination of the terbinafine hydrochloride levels atits action site was needed. We developed a high performance liquid chromatographic (HPLC) method with an appropriate sample pre-treatment (liquid-liquid extraction) for the determination of terbinafine hydrochloride levels in catćs hair. This method showed as more sensitive and faster than other methods published. Hence, it has been modified for the determination of terbinafine hydrochloride levels in hair of children infected with Microsporumcanis and treated with Lamisil tablets. A possible difference between metabolic pathways of the terbinafine hydrochloride in cat and human is suspected on the basis of the experimental data obtained in this experiment. Further and more detailed study is necessary to support this theory.
    Vir: Slovenian veterinary research = Slovenski veterinarski zbornik : the scientific journal of the Veterinary Faculty University of Ljubljana. - ISSN 1580-4003 (Vol. 37, no. 1/2, 2000, str. 107-113)
    Vrsta gradiva - članek, sestavni del
    Leto - 2000
    Jezik - slovenski, angleški
    COBISS.SI-ID - 991610

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