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TPF induction chemotherapy and concomitant irradiation with cisplatin and cetuximab in unresectable squamous cell carcinoma of the head and neckStrojan, Primož ...Background: To assess efficacy and toxicity of TPF induction chemotherapy and concomitant immunochemoradiotherapy with cetuximab and cisplatin in unresectable head and neck carcinoma.Methods: ... Treatment consisted of TPF induction chemotherapy (docetaxel 75 mg/m2 day 2; cisplatin, 75 mg/m2 day 2; and 5-fluorouracil 750 mg/m2 days 1-4; 4 cycles), followed by radiotherapy and concomitant weekly cetuximab, (250 mg/m2, after a loading dose of 400 mg/m2) and cisplatin (30 mg/m2).Results: 25/30 patients completed four cycles of induction chemotherapy. Six or more concomitant infusions of cisplatin and cetuximab were administered in 13/25 and 18/25 patients, respectively. The 2-year locoregional control, disease-free survival and overall survival were 47%, 47%, and 50%, respectively. Patients with grade 2 skin reaction to cetuximab had a superior outcome.Conclusion: The tested regimen was effective; however, cetuximab and low-dose cisplatin after induction TPF increased the treatment toxicity. A grade 2 skin rash correlated with improved efficacy.Vir: Head and neck. - ISSN 1043-3074 (Vol. 36, iss. 11, 2014, str.1555-1561)Vrsta gradiva - članek, sestavni delLeto - 2014Jezik - angleškiCOBISS.SI-ID - 1624443
Avtor
Strojan, Primož |
Grašič-Kuhar, Cvetka |
Žumer, Barbara, 1970- |
Kadivec, Maksimiljan |
Karner, Katarina Barbara |
Fajdiga, Igor |
Jančar, Boris |
Gale, Nina |
Poljak, Mario, 1965- |
Kocjan, Boštjan |
Zakotnik, Branko
Teme
rak glave in vratu |
radioterapija |
ploščatocelični rak |
TPF indukcijska kemoterapija |
konkomitantno obsevanje |
neresektabilni rak |
head and neck cancer |
radiotherapy |
induction TPF chemotherapy
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Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Strojan, Primož | 14576 |
Grašič-Kuhar, Cvetka | 15875 |
Žumer, Barbara, 1970- | 21747 |
Kadivec, Maksimiljan | 08801 |
Karner, Katarina Barbara | 18300 |
Fajdiga, Igor | 16048 |
Jančar, Boris | 09966 |
Gale, Nina | 02127 |
Poljak, Mario, 1965- | 11622 |
Kocjan, Boštjan | 23430 |
Zakotnik, Branko | 11747 |
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