Onkološki inštitut Ljubljana (OILJ)
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The possible role of anti- and protumor-infiltrating lymphocytes in pathologic complete response in early breast cancer patients treated with neoadjuvant systemic therapy [Elektronski vir]Geršak, Klara ...The tumor microenvironment, composed of pro- and antitumor immune cells, affects cancer cell behavior. We aimed to evaluate whether tumor-infiltrating lymphocyte (TIL) density and TIL subtypes in ... core biopsies at the diagnosis of breast cancer patients could predict a pathologic complete response (pCR; ypT0/is ypN0) from neoadjuvant systemic therapy (NST). The TIL subtypes were determined based on the proportions of presumably antitumor (CD8+, CXCL13+) and protumor (PD-1+, FOXP3+) immune cells. A prospective, noninterventional study, including 171 participants undergoing NST, was performed. The median TIL density for the entire cohort was 10% (IQR: 3.5-23.8), and 59 (35%) patients achieved pCR. TIL density was positively associated with pCR (univariately and multivariably). In the multivariable logistic regression model, TIL density was an independent predictor of pCR (p = 0.012, OR 1.27; 95% CI 1.05-1.54) when controlled for age (p = 0.232), Ki-67 (p = 0.001), node-negative status (p = 0.024), and HER2+/triple negative vs. luminal B-like subtype (p < 0.001). In our sample, higher proportions of PD-1+ TILs and FOXP3+ TILs were associated with a higher probability of pCR but the association was not statistically significant and we could not make any conclusions on the direction of associations in the model with all four biomarkers. In the exploratory multivariable analysis, we showed that only higher CD8+ TILs were associated with pCR. In conclusion, TIL density and its subtypes are associated with pCR.Vir: Cancers [Elektronski vir]. - ISSN 2072-6694 (Vol. 15, no. 19, Sep. 2023, 4794-1-4794-20)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2023Jezik - angleškiCOBISS.SI-ID - 174708995
Avtor
Geršak, Klara |
Geršak, Blaž M. |
Gazić, Barbara |
Klevišar Ivančič, Andreja |
Drev, Primož |
Ružić Gorenjec, Nina, 1986- |
Grašič-Kuhar, Cvetka
Teme
rak dojke |
kemokine CXCL13 |
antigen CD8 |
neoadjuvantno sistemsko zdravljenje |
breast neoplasms |
chemokine CXCL13 |
CD8 antigen |
neoadjuvant systemic therapy
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Geršak, Klara | ![]() |
Geršak, Blaž M. | ![]() |
Gazić, Barbara | 20050 |
Klevišar Ivančič, Andreja | ![]() |
Drev, Primož | 22431 |
Ružić Gorenjec, Nina, 1986- | 33230 |
Grašič-Kuhar, Cvetka | 15875 |
Vir: Osebne bibliografije
in: SICRIS
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