Onkološki inštitut Ljubljana (OILJ)
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Influence of control group therapy on the benefit from dose-dense chemotherapy in early breast cancer : a systemic review and meta-analysisGoldvaser, Hadar ...Results from clinical trials of adjuvant dose-dense chemotherapy in patients with breast cancer are inconsistent. METHODS: A systematic search of MEDLINE identified studies comparing the efficacy of ... dose-dense adjuvant chemotherapy to a standard treatment. The primary analysis included studies that used identical regimens in the experimental and control groups, but varied only dose density. A secondary analysis included studies that used either different drugs or doses in the experimental and the control groups. Hazard ratios (HRs) and 95% confidence intervals were computed for disease-free survival (DFS) and overall survival (OS) and pooled in a meta-analysis. Subgroup analyses and meta-regression explored drug schedules utilized in control groups and the influence of clinicopathologic variables on benefit from dose-dense therapy. RESULTS: The primary analysis included 5 studies comprising 9819 patients while the secondary analysis included 6 studies comprising 9679 patients. Dose-dense treatment significantly improved DFS (HR 0.85, p < 0.001) and OS (HR 0.86, p = 0.008) in the primary analysis. Similar results were observed in the secondary analysis. Dose-dense schedule was important primarily in studies utilizing paclitaxel every 3 weeks as the control group (interaction p = 0.04 for DFS interaction p = 0.001 for OS). A significantly greater relative magnitude of benefit was observed in pre-menopausal women and those with nodal involvement, but there was no influence of hormone receptor status on results. CONCLUSIONS: Adjuvant dose-dense regimens improve breast cancer outcomes. It remains uncertain whether the observed benefit reflects the impact of dose density or the inferiority of paclitaxel every 3 weeks as a control group.Vir: Breast cancer research and treatment. - ISSN 0167-6806 (Vol. 169, iss. 3, 2018, str. 413-425)Vrsta gradiva - članek, sestavni delLeto - 2018Jezik - angleškiCOBISS.SI-ID - 2871419
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Ime baze podatkov | Področje | Leto |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Goldvaser, Hadar | ![]() |
Majeed, Habeeb | ![]() |
Ribnikar, Domen | 36202 |
Šeruga, Boštjan, 1973- | 24577 |
Ocaña, Alberto | ![]() |
Cescon, David W. | ![]() |
Amir, Eitan | ![]() |
Vir: Osebne bibliografije
in: SICRIS
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