Background/Aims: While an optimal treatment of chronic hepatitis C has not yet been established, it has been demonstrated that the interferon a/ribavirin combination is more effective than interferon ...a monotherapy. Methodology: One hundred and forty-three patients with chronic hepatitis C received the following treatment: eighty patients an 18-month monotherapy (3-month follow-up) and sixty-three patients a 12-month combined therapy (6-month follow-up). Therapeutic efficacy and adverse effects were compared. Results: In 80 patients in the monotherapy group, complete response was achieved in 49.2 %. This was reduced to 27.5 % three months after therapy. Significant differences were observed in HCV 3 genotype where complete response was achieved in 12 out of 14 patients (p=0.01). With the combined therapy administered to 63 patients, complete response was achieved in 54.5 %.This was reduced to 43.2 % after 6 months of follow-up. Among the responders or partial responders, significant differences were observed with regard to age (p=0.0047) and subtype 1b (p=0.012). Comparing the groups of naive patients and relapsers, a statistically significant difference (p=0.027) was found in therapeutic efficacy. Conclusions: In the treatment of chronic hepatitis C, combined therapy proved more effective than monotherapy. This is, however, not yet a sar=tisfactory solution.
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