Univerzitetna knjižnica Maribor (UKM)
Knjižnica je med tednom odprta od 8. do 19. ure, ob sobotah od 9. do 13. ure. Čitalnica ČUK je odprta od ponedeljka do sobote od 12. do 24. ure, ob nedeljah od 18. do 24. ure. Informacije: 02 25 07 431, ukm@um.si
  • Thefuture of telomere length in personalized medicine [Elektronski vir]
    Gorenjak, Vesna, 1991- ...
    Telomere length has been subject of studies for many decades, aiming to elucidate its role in physiological processes, in process of aging and in diverse pathologies. Yet today, there is still no ... "big title" discovery that would lead to a practical use of telomeres as a reliable biomarker or target for a new drug. However, therapies for chronic disease patients are being tested and companies are already offering commercial tests for telomere length measurement. The strong genetic heritability of telomeres is opening the place for pharmacogenomics researches that could promote the personalized treatment of diverse diseases. In this article, we present the recent knowledge of telomeres genetic determination obtained by genome-wide association studies (GWAS), important biomarkers related to telomere length and review the possibilities of telomere's practical implementation in the medical treatment of diverse diseases and as a potential biomarker in personalized medicine. Furthermore, we summarise commercial offers of telomere length measurements available and we discuss the actions that should be taken to make steps forward into final application of the accumulated knowledge into practical use.
    Vir: Frontiers in bioscience. - ISSN 1093-4715 (Vol. 23, no. 1, Mar. 2018, str. 1628-1654)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2018
    Jezik - angleški
    COBISS.SI-ID - 56781059

    Povezava(-e):

    https://pdfs.semanticscholar.org/bdcc/217de2ec3b58d2277b504153d561fb3e27e3.pdf
    DOI

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