(UL)
  • Liječenje anemije zbog nedonošenosti rekombinantnim humanim eritropoetinom : magistrski rad
    Kornhauser-Cerar, Lilijana, 1958-
    The anemia of prematurity (AOP) is invariably observed in very low birth weight (VLBW) infants and may become symptomatic enough to require treatment with packed red cell transfusions, that subject ... patients to numerous potentialadverse effects. Experimental and clinical data implicate inadequate erythropoietin production as an important reason that these infants acquire anemia. The recent availability of recombinant human erythropoietin (rHuEPO) has raised the possibility of stimulating erythropoiesis and thereby reduce the need for transfusions especially in the group of VLBW infants. The aim of this prospective randomized controlled trial was to assess the benefits and risks of erythropoietin omega, which has until now not been used in the treatment of AOP, versus erythrocyte transfusion. We hypothesized that using alow dose of erythropoietin omega in VLBW infants would stimulate erythropoiesis, and thus reduce postnatal hemoglobin decline and the transfusion requirements. Moreover, the cost of this treatment was compared with that of conventional therapy, consisting of erythrocyte transfusions alone. Forty-six preterm infants born at less than 31 weeks of gestation who weighed 1500 g or less at birth were randomly assigned to two groupsČ rHuEPO omega was given to infants in group A (N = 23), while group B (N = 23) served as control group and the infants did not receive this drug. Infants in group Awere receiving subcutaneously 300 IUžkgžweek of erythropoietin omega (Epomax TM) for four weeks. The treatment was started at 2 -7 weeks of postnatal age (mean 26,3 days). All patients received supplemental oral iron (3 mgžkgžday) and vitamin E therapy (5 mgžday) and were managed according to uniform transfusion guidelines. (Abstract truncated at 2000 characters).
    Vrsta gradiva - magistrsko delo ; neleposlovje za odrasle
    Založništvo in izdelava - Zagreb : [L. Kornhauser Cerar], 2000
    Jezik - hrvaški
    COBISS.SI-ID - 2285076

Knjižnica Signatura – lokacija, inventarna št. ... Status izvoda
MF, Centralna medicinska knjižnica, Ljubljana magistrske naloge
KORNHAUSER Cerar L. Liječenje
IN: 020010587 		prosto - na dom, čas izposoje: 1 mes.
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