(UL)
  • Increased apolipoprotein E gene expression and protein concentration in lung cancer tissue do not contribute to the clinical assessment of non-small cell lung cancer patients
    Trošt, Zoran, 1979- ...
    Background We tested the hypothesis that apolipoprotein E (apo E) gene expression and protein concentration are increased in resectable non-small cell lung cancer tissue and that these apo E tissue ... estimations may be benefitially used in clinical assessment of non-small cell lung cancer patients.Methods Paired samples of lung cancer and adjacent, appartently healthy, non-cancer lung tissue were collected from 42 patients with resectable non-small cell lung cancer. Apo E gene expression in tissue was measured by quantitative PCR. Apo E protein in tissue and serum was quantifiedby a nephelometric method. Patients were followed for 3 years. Results Apo E gene expression and protein concentration were 1.6 and 4.1-fold higher in the cancer tissue than in the adjacent non-cancer tissue (p <0.0001 in both cases). Increase of apo E protein concentration in the cancer tissue (relative to the non-cancer tissue) correlated with the decrease of apo E protein concentration in the serum (p = 0.021). However, none of these apo E estimations related to stage of cancer or histological type of tumor and do not predict patient survival. Conclusions Our preliminary study shows that despite the distinct increase of apo E gene expression and protein concentration in the cancer tissue and the concurrent decrease of apo E protein concentration in the serum, the measured apo E values have limited usefulness in clinical assessment of patients with resectable non-small cell lung cancer.
    Vir: Archives of medical research. - ISSN 0188-4409 (Vol. 39, no. 7, 2008, str. 663-667)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - angleški
    COBISS.SI-ID - 2373233

vir: Archives of medical research. - ISSN 0188-4409 (Vol. 39, no. 7, 2008, str. 663-667)

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