(UL)
  • C-reaktivni protein in skrajna levkocitoza v diagnostiki akutno nastale vročine brez žariščnih znakov bolezni pri otrocih = Diagnostic value of C-reactive protein and extreme leukocytosis in febrile children without localizing signs
    Tonin, Irena, medicina ; Vidmar Šimic, Marijana ; Čižman, Milan
    Background. Determining the level of C-reactive protein assists in the detection of serious bacterial infections. The value of C-reactive protein is higher in bacterial infections and remains low in ... viral infections. However, there is no clear cut-off value between bacterial and viral infections hence the C-reactive protein value alone is insufficient to determine the cause of the infection. Aim. The purpose of our study was to establish the importance of indicators of acute infection, which can be routinely checked in children suffering from acute fever who do not have a localized infection. We aimed to determine whether extreme leucocytosis increases the likelihood that the childis suffering from a bacterial infection, which should be treated with antibiotics. Our aim was also to establish the importance of repeated determination of the indicators of infection in acutely febrile children without localizing signs. Methods. The retrospective research included 333 children aged 0 to 14 years, who were diagnosed as febrile state in 2003 andreferred to the University Medical Centre, Department of Infecrious Diseases in Ljubljana. For a more comprehensive classification of invasive bacterial infections we also examined an additional 26 records from the years 2004 and 2005, where the diagnosis was either bacteraemia or meningitis. Student's t-test, Mann-Whitney U-test and hi-square test were used to compare the values of the bacterial and viral infections. The differences were considered statistically significant when the level of risk was less than 0.05(p < 0.05). Results. The sensitivity of C-reactive protein with a leucocyte count of > 15.0 X 109/1 was 72.8 % and specificiiy was 67.2%, PPV 73% and NPV 67%. (Abstract truncated at 2000 characters)
    Vir: Slovenska pediatrija : revija Združenja pediatrov Slovenije in Združenja specialistov šolske in visokošolske medicine Slovenije. - ISSN 1318-4423 (Letn. 14, št. 4, 2007, str. 160-168)
    Vrsta gradiva - članek, sestavni del
    Leto - 2007
    Jezik - slovenski
    COBISS.SI-ID - 23924953

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