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  • Redox control of protein degradation [Elektronski vir]
    Pajares, Marta ...
    Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant ... protein modification, as well as the impact of reactive oxygen species on the proteolytic systems that regulate cell response to an oxidant environment: the ubiquitin-proteasome system (UPS), autophagy and the unfolded protein response (UPR). In the presence of an oxidant environment, these systems are critical to ensure proteostasis and cell survival. An example of altered degradation of oxidized proteins in pathology is provided for neurodegenerative diseases. Future work will determine if protein oxidation is a valid target to combat proteinopathies.
    Vir: BioMed research international [Elektronski vir]. - ISSN 2314-6141 (Vol. 6, Sep. 2015, str. 409-420)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 32219097

    Povezava(-e):

    http://www.sciencedirect.com/science/article/pii/S2213231715000750
    DOI

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