(UL)
  • Pomen prostatičnega specifičnega antigena (PSA) pri diagnostiki raka prostate = Significance of prostate specific antigen in the diagnosis of prostate cancer
    Sedmak, Boris
    Background. Prostate cancer is among the most common cancers in men. The incidence of this malignancy in Slovenia is increasing. An optimal treatment has not been found yet and only organ-confined ... disease is potentially curable by radical prostatectomy. Therefore, early detection and treatment are important. The aim of this study was to assess the usefulness of prostate specific antigen (PSA) and prostate specific angiten density (PSAD) in early detection of prostate cancer. We determined and compared the predictive value of positive PSA and PSAD test. Patients and methods. The study population consisted of 171 patients who were referred for further evaluation of suspected prostate cancer. Each patient underwent a digital rectal examinationand transrectal ultrasonography, the volume of the prostate gland was determined, the serum PSA level measured and PSAD calculated. Transrectal ultrasound-guided prostatic biopsy was performed in patients with the digital rectal examination suggestive of prostate cancer or a serum PSA level equal toor higher than 4 ng/ml. Results. The PSA assay with low cutoff values provedto have a high sensitivity and comparatively low specificity in the detection of prostate cancer. By determining the serum PSA level, we were ableto detect carcinomas at an early stage when they were not yet palpable on digital rectal examination. PSAD had a higher preditive value than PSA. Conclusions. PSA is highly specific marker of prostate gland tissue, malignantand nonmalignant. The PSA assay with low cutoff values is higly sensitive but its specificity is slow. By means of serum PSA measurement it ispossible to detect organ-confined carcinomas that are not palpable on digital rectal examination. PSAD determination increases the positive predictive value of PSA. The number of negative prostatic biopsies could be reduced by observing a PSAD value of 0.15 as an indication for biopsy in the absence of palpable lesion.
    Vir: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Let. 66, št. 9, 1997, str. 473-476)
    Vrsta gradiva - članek, sestavni del
    Leto - 1997
    Jezik - slovenski
    COBISS.SI-ID - 6931673

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