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The potential of macroporous silica-nanocrystalline cellulose combination for formulating dry emulsion systems with improved flow properties [Elektronski vir] : a DoE studyPohlen, Mitja ; Pirker, Luka ; Dreu, RokThe objective of this study was to explore the possible use of a new combination of two excipients, i.e., nanocrystalline cellulose (NCC) and macroporous silica (MS), as matrix materials for the ... compounding of dry emulsion systems and the effects these two excipients have on the characteristics of dry emulsion powders produced by the spray drying process. A previously developed liquid O/W nanoemulsion, comprised of simvastatin, 1-oleoyl-rac-glycerol, Miglyol 812 and Tween 20, was employed. In order to comprehend the effects that these two matrix formers have on the spray drying process and on dry emulsion powder characteristics, alone and in combination, a DoE (Design of Experiment) approach was used. The physicochemical properties of dry emulsion samples were characterised by atomic force microscopy, scanning electron microscopy, mercury intrusion porosimetry, energy-dispersive X-ray spectroscopy and laser diffraction analysis. Additionally, total release and dissolution experiments were performed to assess drug release from multiple formulations. It was found that the macroporous silica matrix drastically improved flow properties of dry emulsion powders; however, it partially trapped the oil-drug mixture inside the pores and hindered complete release. NCC showed its potential to reduce oil entrapment in MS, but because of its rod-shaped particles deposited on the MS surface, powder flowability was deteriorated.Vir: Pharmaceutics [Elektronski vir]. - ISSN 1999-4923 (Vol. 13, iss. 8, 2021, str. 1-24)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2021Jezik - angleškiCOBISS.SI-ID - 72824835
Avtor
Pohlen, Mitja |
Pirker, Luka |
Dreu, Rok
Teme
Dostavni sistem |
Emulzije |
suhe emulzije |
nanokristalinska celuoza |
sušenje z razprševanjem |
makroporozni kremen |
pretočnost |
simvastatin |
dry emulsion |
lipid-based drug delivery systems |
nanocrystalline cellulose |
macroporous silica |
spray drying |
flowability |
DoE
Avtor | Pohlen, Mitja ; Pirker, Luka ; Dreu, Rok |
Naslov | The potential of macroporous silica-nanocrystalline cellulose combination for formulating dry emulsion systems with improved flow properties [Elektronski vir] : a DoE study |
Datum objave | 2021-07-30 |
COBISS.SI-ID | 72824835 |
Verzija objave v repozitoriju | Založnikova različica |
Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva 4.0 Mednarodna |
Embargo | Takojšnja javna objava |
Projekti, iz katerih je bila financirana objava
Naziv | Akronim | Številka projekta | Financer |
---|---|---|---|
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Fizika mehkih snovi, površin in nanostruktur | P1-0099-2015 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Datoteke, ki spadajo k objavi
Povezava |
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https://www.mdpi.com/1999-4923/13/8/1177 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=135951 |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Pohlen, Mitja | 50269 |
Pirker, Luka | 38194 |
Dreu, Rok | 21455 |
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