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Oikonomou, Evangelos; Tsalamandris, Sotiris; Karlis, Dimitris; Siasos, Gerasimos; Chrysohoou, Christina; Vogiatzi, Georgia; Dimitropoulos, Stathis; Charalambous, Georgios; Kouskouni, Evangelia; Tousoulis, Dimitris
Biomarkers in medicine, 2018-December-01, 20181201, 2018-12-00, Letnik: 12, Številka: 12Journal Article
The NGAL is a biomarker of renal injury associated with the progression of heart failure (HF). We examine the association of NGAL with galectin-3 in patients with chronic HF. We consecutively enrolled 115 subjects with stable ischemic HF of reduced ejection fraction. Serum levels of galectin-3, b-type natriuretic peptide and NGAL were measured. NGAL levels were positively correlated with galectin-3 (rho = 0.26; p = 0.04) and b-type natriuretic peptide levels (rho = 0.30; p = 0.005) and inversely correlated with ejection fraction (rho = -0.31; p = 0.02) and creatinine clearance levels. The NGAL was independently associated with galectin-3 levels. A positive correlation between NGAL and galectin-3 in HF patients was found, revealing a potential association between renal injury and myocardial fibrosis and remodeling in HF.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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