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Ode, Yudai; Pradipta, Ambara R; Ishiwata, Akihiro; Nambu, Akihiro; Ohnuki, Kazunobu; Mizuma, Hiroshi; Haba, Hiromitsu; Tanaka, Katsunori
Chemical communications (Cambridge, England), 03/2024, Letnik: 6, Številka: 24Journal Article
This study proposes a new method for radionuclide therapy that involves the use of oligomeric 2,6-diisopropylphenyl azides and a chelator to form stable complexes with metallic radionuclides. The technique works by taking advantage of the endogenous acrolein produced by cancer cells. The azides react with the acrolein to give a diazo derivative that immediately attaches to the nearest organelle, effectively anchoring the radionuclide within the tumor. Preliminary in vivo experiments were conducted on a human lung carcinoma xenograft model, demonstrating the feasibility of this approach for cancer treatment. Oligomeric 2,6-diisopropylphenyl azides, equipped with chelators to form stable complexes with metallic radionuclides, were developed as a new radionuclide therapy method that takes advantage of endogenous acrolein overproduced by cancer cells.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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