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Reijerkerk, Arie; Lopez-Ramirez, M Alejandro; van Het Hof, Bert; Drexhage, Joost A R; Kamphuis, Wouter W; Kooij, Gijs; Vos, Joost B; van der Pouw Kraan, Tineke C T M; van Zonneveld, Anton J; Horrevoets, Anton J; Prat, Alexandre; Romero, Ignacio A; de Vries, Helga E
The Journal of neuroscience, 2013-Apr-17, 2013-04-17, 20130417, Letnik: 33, Številka: 16Journal Article
Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. In particular, miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux. Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS.
