E-viri
Recenzirano
-
Silva Torres, Daniel; Alves de Oliveira, Bruna; Souza d Silveira, Lígia; Paulo da Silva, Marcos; Rodrigues Durães Pereira, Vinícius; Moraes, Josué; Rúbia Costa Couri, Mara; Fortini Grenfell e Queiroz, Rafaella; Martins Parreiras, Patrícia; Roberto Silva, Márcio; Azevedo Alves, Lara; Carius de Souza, Vinícius; Vanessa Zabala Capriles Goliatt, Priscila; Gomes Vasconcelos, Eveline; Alves da Silva Filho, Ademar; Faria Pinto, Priscila
Chemistry & biodiversity, November 2021, 2021-Nov, 2021-11-00, 20211101, Letnik: 18, Številka: 11Journal Article
In this work, two synthetic aurones revealed moderate schistosomicidal potential in in vitro and in vivo assays. Aurones (1) and (2) promoted changes in tegument integrity and motor activity, leading to death of adult Schistosoma mansoni worms in in vitro assays. When administered orally (two doses of 50 mg/kg) in experimentally infected animals, synthetic aurones (1) and (2) promoted reductions of 56.20 % and 57.61 % of the parasite load and stimulated the displacement towards the liver of the remaining adult worms. The oogram analysis revealed that the treatment with both aurones interferes with the egg development kinetics in the intestinal tissue. Seeking an action target for compounds (1) and (2), the connection with NTPDases enzymes, recognized as important therapeutic targets for S. mansoni, was evaluated. Molecular docking studies have shown promising results. The dataset reveals the anthelmintic character of these compounds, which can be used in the development of new therapies for schistosomiasis.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.