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Caldiroli, Lara; Armelloni, Silvia; Eskander, Alessandra; Messa, Piergiorgio; Rizzo, Vittoria; Margiotta, Elisabetta; Cesari, Matteo; Vettoretti, Simone
Experimental gerontology, 20/May , Letnik: 147Journal Article
in patients with chronic kidney disease (CKD) indoxyl sulfate (IS) and p-cresyl sulfate (PCs) may induce sarcopenia either directly or via systemic inflammation. We evaluated whether IS and PCs were associated with: sarcopenia, systemic inflammation and nutritional status. Methods: we examined cross sectionally 93 patients with advanced CKD. Sarcopenia was identified according to EWGSOP2 definition. Malnutrition was assessed by Malnutrition Inflammation Score (MIS) and Protein Energy Wasting syndrome (PEW). Inflammatory status was assessed by dosing: CRP, IL6, TNFα, MCP1, IL10, IL17, IL12p70. Results: we did not find any association of sarcopenia with IS and PCs. IS was associated with LogTNFα and LogMCP-1 in the overall cohort (r = 0.30, p = 0.0043; r = 0.22 p = 0.047) and in not sarcopenic patients (r = 0.32, p = 0.0077; r = 0.25, p = 0.041). PCs was associated with LogIL10 and LogIL12p70 in sarcopenic patients (r = 0.58, p = 0.0042; r = 0.52, p = 0.013). IS was higher in patients without PEW (p = 0.029), while PCs was higher in patients with PEW (p = 0.0040). IS and PCs were not different in patients with normal or increased MIS. Conclusions: IS and PCs were not associated with sarcopenia, although they were both associated with some inflammatory pathways. Notably, we found a positive association of PCs with PEW syndrome. •In older patients with advanced chronic kidney disease IS and PCs are not associated with sarcopenia.•In older patients with advanced chronic kidney disease IS and PCs are associated with different inflammatory patterns in sarcopenic and not sarcopenic individuals.•In older patients with advanced chronic kidney disease PCs is higher in patients with protein energy wasting syndrome (PEW), while IS was not associated with PEW.
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