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Saito, Kazuki; Kratzat, Hanna; Campbell, Annabelle; Buschauer, Robert; Burroughs, A Maxwell; Berninghausen, Otto; Aravind, L; Green, Rachel; Beckmann, Roland; Buskirk, Allen R
Nature, 03/2022, Letnik: 603, Številka: 7901Journal Article
Ribosome rescue pathways recycle stalled ribosomes and target problematic mRNAs and aborted proteins for degradation . In bacteria, it remains unclear how rescue pathways distinguish ribosomes stalled in the middle of a transcript from actively translating ribosomes . Here, using a genetic screen in Escherichia coli, we discovered a new rescue factor that has endonuclease activity. SmrB cleaves mRNAs upstream of stalled ribosomes, allowing the ribosome rescue factor tmRNA (which acts on truncated mRNAs ) to rescue upstream ribosomes. SmrB is recruited to ribosomes and is activated by collisions. Cryo-electron microscopy structures of collided disomes from E. coli and Bacillus subtilis show distinct and conserved arrangements of individual ribosomes and the composite SmrB-binding site. These findings reveal the underlying mechanisms by which ribosome collisions trigger ribosome rescue in bacteria.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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