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Bonheur, Ashley N; Thomas, Sarah; Soshnick, Sara H; McGibbon, Emily; Dupuis, Alan P; Hull, Rene; Slavinski, Sally; Del Rosso, Paula E; Weiss, Don; Hunt, Danielle T; McCabe, Megan E; Dean, Amy B; Folkerth, Rebecca; Laib, Anne M; Wong, Susan J
BMC infectious diseases, 08/2021, Letnik: 21, Številka: 1Journal Article
Dengue virus (DENV) is endemic in many parts of the world. Antibody dependent enhancement (ADE) in DENV infections occurs when a person with primary immunity is infected by a second, different DENV strain. Antibodies to Zika virus (ZIKV), which emerged in the Western Hemisphere in 2015, are cross reactive with DENV and theoretically could provoke ADE in a DENV naïve individual. We report the first known patient in the United States with a rapidly progressive and fatal case of travel-associated DENV in which prior exposure to ZIKV likely played a role in triggering an ADE phenomenon. This association of prior ZIKV immunity and subsequent new dengue infection is a worrisome phenomenon and an important contribution to the body of knowledge on immunity to flaviviruses.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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