E-viri
Recenzirano
Odprti dostop
-
Wei, Wei; Tuna, Salih; Keogh, Michael J; Smith, Katherine R; Aitman, Timothy J; Beales, Phil L; Bennett, David L; Gale, Daniel P; Bitner-Glindzicz, Maria A K; Black, Graeme C; Brennan, Paul; Elliott, Perry; Flinter, Frances A; Floto, R Andres; Houlden, Henry; Irving, Melita; Koziell, Ania; Maher, Eamonn R; Markus, Hugh S; Morrell, Nicholas W; Newman, William G; Roberts, Irene; Sayer, John A; Smith, Kenneth G C; Taylor, Jenny C; Watkins, Hugh; Webster, Andrew R; Wilkie, Andrew O M; Williamson, Catherine; Ashford, Sofie; Penkett, Christopher J; Stirrups, Kathleen E; Rendon, Augusto; Ouwehand, Willem H; Bradley, John R; Raymond, F Lucy; Caulfield, Mark; Turro, Ernest; Chinnery, Patrick F
Science (American Association for the Advancement of Science), 05/2019, Letnik: 364, Številka: 6442Journal Article
Approximately 2.4% of the human mitochondrial DNA (mtDNA) genome exhibits common homoplasmic genetic variation. We analyzed 12,975 whole-genome sequences to show that 45.1% of individuals from 1526 mother-offspring pairs harbor a mixed population of mtDNA (heteroplasmy), but the propensity for maternal transmission differs across the mitochondrial genome. Over one generation, we observed selection both for and against variants in specific genomic regions; known variants were more likely to be transmitted than previously unknown variants. However, new heteroplasmies were more likely to match the nuclear genetic ancestry as opposed to the ancestry of the mitochondrial genome on which the mutations occurred, validating our findings in 40,325 individuals. Thus, human mtDNA at the population level is shaped by selective forces within the female germ line under nuclear genetic control, which ensures consistency between the two independent genetic lineages.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.