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Garrido Ruiz, Patricia Alejandra; Rodriguez, Álvaro Otero; Corchete, Luis Antonio; Zelaya Huerta, Victoria; Pasco Peña, Alejandro; Caballero Martínez, Cristina; González-Carreró Fojón, Joaquín; Catalina Fernández, Inmaculada; López Duque, Juan Carlos; Zaldumbide Dueñas, Laura; Mosteiro González, Lorena; Astudillo, María Aurora; Hernández-Laín, Aurelio; Camacho Urkaray, Emma Natalia; Viguri Diaz, María Amparo; Orfao, Alberto; Tabernero, María Dolores
Biology (Basel, Switzerland), 2024-May-16, Letnik: 13, Številka: 5Journal Article
Rhabdoid meningiomas (RM) are a rare meningioma subtype with a heterogeneous clinical course which is more frequently associated with recurrence, even among tumors undergoing-complete surgical removal. Here, we retrospectively analyzed the clinical-histopathological and cytogenetic features of 29 tumors, from patients with recurrent (seven primary and 14 recurrent tumors) vs. non-recurrent RM ( = 8). Recurrent RM showed one (29%), two (29%) or three (42%) recurrences. loss of expression was found in one third of all RM at diagnosis and increased to 100% in subsequent tumor recurrences. Despite both recurrent and non-recurrent RM shared chromosome 22 losses, non-recurrent tumors more frequently displayed extensive losses of chromosome 19p (62%) and/or 19q (50%), together with gains of chromosomes 20 and 21 (38%, respectively), whereas recurrent RM (at diagnosis) displayed more complex genotypic profiles with extensive losses of chromosomes 1p, 14q, 18p, 18q (67% each) and 21p (50%), together with focal gains at chromosome 17q22 (67%). Compared to paired primary tumors, recurrent RM samples revealed additional losses at chromosomes 16q and 19p (50% each), together with gains at chromosomes 1q and 17q in most recurrent tumors (67%, each). All deceased recurrent RM patients corresponded to women with chromosome 17q gains, although no statistical significant differences were found vs. the other RM patients.
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in: SICRIS
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