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Pfefferle, Petra Ina, PhD, DrPH; Büchele, Gisela, MPH; Blümer, Nicole, PhD; Roponen, Marjut, PhD; Ege, Markus Johannes, MD, MPH; Krauss-Etschmann, Susanne, MD; Genuneit, Jon; Hyvärinen, Anne, PhD; Hirvonen, Maija-Riitta, PhD; Lauener, Roger, MD; Pekkanen, Juha, MD; Riedler, Josef, MD; Dalphin, Jean Charles, MD, PhD; Brunekeef, Bert, PhD; Braun-Fahrländer, Charlotte, MD; von Mutius, Erika, MD, MSc; Renz, Harald, MD
Journal of allergy and clinical immunology, 2010, January 2010, 2010-Jan, 2010-01-00, 20100101, 2010-01, Letnik: 125, Številka: 1Journal Article
Background Traditional farming represents a unique model situation to investigate the relationship of early-life farm-related exposure and allergy protection. Objectives To investigate associations between maternal farm exposures and cytokine production in cord blood (CB) mononuclear cells in a prospective multinational birth cohort of 299 farm and 326 nonfarm children and their families. Methods Supernatants from phorbol 12-myristate 13-acetate/ionomycin–stimulated CB mononuclear cells were assessed for the production of IFN-γ, TNF-α, IL-5, IL-10, and IL-12. Results Significantly higher levels of IFN-γ and TNF-α in farm compared with nonfarm children were found, whereas IL-5, IL-10, and IL-12 levels did not differ between study groups. Maternal contact with different farm animal species and barns and consumption of farm-produced butter during pregnancy enhanced the production of proinflammatory CB cytokines, whereas maternal consumption of farm-produced yogurt resulted in significant lower levels of IFN-γ and TNF-α in umbilical blood. Conclusion Maternal exposure to farming activities and farm dairy products during pregnancy modulated cytokine production patterns of offspring at birth.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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