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    Mendel, Marta; Chlopecka, Magdalena; Dziekan, Natalia; Karlik, Wojciech; Wiechetek, Maria

    Journal of ethnopharmacology, 03/2013, Letnik: 146, Številka: 1
    Journal Article

    Ethnopharmacological relevance The dry extract of Hedera helix leaves, due to its secretolytic and antispasmodic effects, is commonly used to produce pharmaceuticals applied in case of cough and other respiratory symptoms. The results of some in vitro studies as well as the clinical signs of poisoning caused by Hedera helix suggest however strong contractile effect on smooth muscle. In order to clarify the impact of alpha-hederin (the main active agent of ivy extract) on smooth muscle, the origin of activated calcium involved in alpha-hederin-induced contraction of gastric smooth muscle preparations was studied.