E-viri
Recenzirano
Odprti dostop
-
Petersen, Julian; Englmaier, Lukas; Artemov, Artem V; Poverennaya, Irina; Mahmoud, Ruba; Bouderlique, Thibault; Tesarova, Marketa; Deviatiiarov, Ruslan; Szilvásy-Szabó, Anett; Akkuratov, Evgeny E; Pajuelo Reguera, David; Zeberg, Hugo; Kaucka, Marketa; Kastriti, Maria Eleni; Krivanek, Jan; Radaszkiewicz, Tomasz; Gömöryová, Kristína; Knauth, Sarah; Potesil, David; Zdrahal, Zbynek; Ganji, Ranjani Sri; Grabowski, Anna; Buhl, Miriam E; Zikmund, Tomas; Kavkova, Michaela; Axelson, Håkan; Lindgren, David; Kramann, Rafael; Kuppe, Christoph; Erdélyi, Ferenc; Máté, Zoltán; Szabó, Gábor; Koehne, Till; Harkany, Tibor; Fried, Kaj; Kaiser, Jozef; Boor, Peter; Fekete, Csaba; Rozman, Jan; Kasparek, Petr; Prochazka, Jan; Sedlacek, Radislav; Bryja, Vitezslav; Gusev, Oleg; Adameyko, Igor
Nature communications, 2023, Letnik: 14, Številka: 1Journal Article
In this study we use comparative genomics to uncover a gene with uncharacterized function (1700011H14Rik/C14orf105/CCDC198), which we hereby name FAME (Factor Associated with Metabolism and Energy). We observe that FAME shows an unusually high evolutionary divergence in birds and mammals. Through the comparison of single nucleotide polymorphisms, we identify gene flow of FAME from Neandertals into modern humans. We conduct knockout experiments on animals and observe altered body weight and decreased energy expenditure in Fame knockout animals, corresponding to genome-wide association studies linking FAME with higher body mass index in humans. Gene expression and subcellular localization analyses reveal that FAME is a membrane-bound protein enriched in the kidneys. Although the gene knockout results in structurally normal kidneys, we detect higher albumin in urine and lowered ferritin in the blood. Through experimental validation, we confirm interactions between FAME and ferritin and show co-localization in vesicular and plasma membranes.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.